I mounted a Condor wheel chock on the drivers side in the garage with no problems. It had to be mounted snug to the forward wall for the Harley to fit with the ramp door closed.
There were no issues underneath with wires/plumbing or frame braces.
All you are drilling thru for holes is the floor covering and the wood floor - 3/4 inch plywood IIRC so the mounting bolts 1.5 or 2 inch long will be adequate depending on thickness of metal or large washer you slip on the bolt before the lockwasher/nut. I was going to use a length of angle iron but settled on some very large metal washers .... about 3" in diameter.
2012 Fun Finder XT 276 Toy Hauler & Harley Davidson Ultra Classic with Condor wheel chock
2014 Dodge Ram 2500 AT 4X4 Crew Cab 6.4 L Hemi, 373 gears, tow package, Rambox option, Revolver X2 tonneau cover, Equal-I-zer anti-sway hitch.